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27.  Pichon, M., Drelinkiewicz, D., Lozano, D., Moraru, R., Hayward,
       L., Jones, M., McCoy, M., Allstrum-Graves, S., Balourdas, D-I.,
       Joerger, A., Whitby, R., Goldup, S., Wells, N., Langley, G.,   
       Herniman, J., B
aud, M. G. J.
       Structure–Reactivity Studies of 2-Sulfonylpyrimidines Allow 
       Selective Protein Arylation
       ACS Bioconjugate Chemistry, 34, 9, 1679–1687 (2023)
       DOI: 10.1021/acs.bioconjchem.3c00322

       ChemRxiv. Cambridge: Cambridge Open Engage (2023)
       DOI: 10.26434/chemrxiv-2023-cx8vk


26. Schlotawa, L., Tyka, K., Kettwig, M., Ahrens‐Nicklas, R.C., Baud,
      M., Berulava, T., Brunetti‐Pierri, N., Gagne, A., Herbst, Z.M.,
      Maguire, J.A. and Monfregula, J.,

      Drug screening identifies tazarotene and bexarotene as
      therapeutic agents in multiple sulfatase deficiency

      EMBO Molecular Medicine,e14837, (2023)
      DOI: 10.15252/emmm.202114837


25.  Stephenson Clarke, J. R., Douglas, L. R., Duriez, P. J.,
       Balourdas​ D-I., Joerger, A. C., Khadiullina, R., Bulatov, E.,
       Baud, M. G. J.

       Discovery of Nanomolar-Affinity Pharmacological Chaperones
       Stabilizing the Oncogenic p53 Mutant Y220C

       ACS Pharmacology and Translational Science,
       5, 1169-1180 (2022)

       DOI: 10.1021/acsptsci.2c00164

24.  McCoy, M. A., Spicer, D., Wells, N., Hoogewijs, K., Fiedler,
       M., Baud, M. G. J.

       Biophysical Survey of Small-Molecule β-Catenin Inhibitors:         A Cautionary Tale
       Journal of Medicinal Chemistry, 65, 7246-7261 (2022)
       DOI: 10.1021/acs.jmedchem.2c00228

Mikes paper graphical absrtact.jpeg

22.  Troup, R. I., Fallan, C., Baud, M. G. J. 
       Current strategies for the design of PROTAC linkers: a critical review
       Exploration of Targeted Anti-tumor Therapy, 1, 273-312, (2020)
       DOI: 10.37349/etat.2020.00018


21.  Chasov, V., Mirgayazova, R., Zmievskaya, E., Khadiullina, R., Valiullina, 
       A., Stephenson Clarke, J., Rizvanov, A., Baud, M.,
 Bulatov, E. 
       Key Players in the Mutant p53 Team: Small Molecules, Gene
       Editing, Immunotherapy
       Frontiers in Oncology, 10, 1460, (2020).
       DOI: 10.3389/fonc.2020.01460

Key players in the mutant p53 team.png

20.  Schlotawa, L., Kettwig, M., Radhakrishnan, K., Dierks, T.,
       Gartner, J. and Baud, M.,
       Method for the treatment of diseases associated with sulfatase
       (2020), US application pending.

19.  Baud, M. G. J., Bauer, M. R., Verduci, L., Dingler, F. A., Patel,
       K. J., Horil Roy, D., ... Fersht, A. R. 
       Aminobenzothiazole derivatives stabilize the thermolabile p53                   cancer mutant Y220C and show anticancer activity in p53-                       Y220C cell lines. 
       European Journal of Medicinal Chemistry, 152, 101-114, (2018)
       DOI: 10.1016/j.ejmech.2018.04.035

Eur J Med chem 2018 graphical abstract.j

18.  Runcie, A. C., Zengerle, M., Chan, K-H., Testa, A., van
       Beurden, L., Baud, M. G. J., ... Ciulli, A.
       Optimization of a “bump-and-hole” approach to allele-selective
       BET bromodomain inhibition. 
       Chemical Science, (2018)
       DOI: 10.1039/C7SC02536J

Bump and hole.jpg

17.  Khan, R., Marsh, G., Felix, R., Kemmitt, P. D., Baud, M. G. J.,
       Ciulli, A., & Spencer, J.
       Gram scale laboratory synthesis of TC AC 28, a high affinity 
       BET bromodomain ligand. 

       ACS Omega, 2(8), 4328-4332, (2017
       DOI: 10.1021/acsomega.7b00780

Gram scale lab synthesis.gif

16.  Weston, C. E., Krämer, A., Colin, F., Yildiz, Ö., Baud, M. G. J.,
       Meyer-Almes, F-J., & Fuchter, M. J.
       Toward photopharmacological antimicrobial chemotherapy 
photoswitchable amidohydrolase inhibitors. 

       ACS Infectious Diseases, 3(2), 152-161, (2017
       DOI: 10.1021/acsinfecdis.6b00148

Towards photopharmacological.gif

15.  Bauer, M. R., Jones, R. N., Baud, M., Wilcken, R., Boeckler, F.
       M., Fersht, A. R., ... Spencer, J.
       Harnessing fluorine–sulfur contacts and multipolar interactions
       for the design of p53 mutant Y220C rescue drugs. 

       ACS Chemical Biology, 11(8), 2265-2274, (2016
       DOI: 10.1021/acschembio.6b00315

Harnessing fluorine.gif

14.  Baud, M., Lin-Shiao, E., Zengerle, M., Tallant, C., & Ciulli, A.
       New synthetic routes to triazolo-benzodiazepine analogues:                 expanding the scope of the bump-and-hole approach for
       selective bromo and extra-terminal (bet) bromodomain inhibition. 

      Journal of Medicinal Chemistry, 59(4), 1492-1500, (2016)  
      DOI: 10.1021/acs.jmedchem.5b01135

new synthetic routes.gif

13.  Shiao, E. L., Baud, M. G. J., Cuilli, A., Chan, K-H., Zengerle, M.,
       Enzyme Functional Probes 
       WO 2015/079259

12.  Richardson, R. D., Baud, M., Weston, C. E., Rzepa, H. S.,
       Kuimova, M. K., & Fuchter, M. J.  
       Dual wavelength asymmetric photochemical synthesis with 
polarized light

       Chemical Science, 6(7), 3853-3862, (2015)
       DOI: 10.1039/C4SC03897E

Dual wavelength.gif

11.  Joerger, A. C., Bauer, M. R., Wilcken, R., Baud, M., Harbrecht,

H., Exner, T. E., ... Fersht, A. R.  

Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53

Structure, 23(12), 2246-2255, (2015)

DOI: 10.1016/j.str.2015.10.016

Structure 2015 graphical abstract.png

10.  Baud, M. G. J., Lin-Shiao, E., Cardote, T., Tallant, C.,

Pschibul, A., Chan, K-H., ... Ciulli, A.

A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

Science, 346(6209), 638-641, (2014

DOI: 10.1126/science.1249830

Science 2014 paper graphical abstract (3
Science 2014 paper graphical abstract (2
Science 2014 paper graphical abstract (1

9.    Meyners, C., Baud, M., Fuchter, M. J., & Meyer-Almes, F-J.

Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors

Analytical Biochemistry, 460, 39-46, (2014

DOI: 10.1016/j.ab.2014.05.014

Meyners 2014.png

8.    Dias, D. M., Van Molle, I., Baud, M., Galdeano, C.,

Geraldes, C. F. G. C., & Ciulli, A. Letter.

Is NMR fragment screening fine-tuned to assess druggability of protein–protein interactions? 

ACS Medicinal Chemistry Letters, 5(1), 23-28, (2014

DOI: 10.1021/ml400296c

is nmr fragment.gif

7.    Meyners, C., Baud, M., Fuchter, M. J., & Meyer-Almes, F-J.

Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes. 

Journal of Molecular Recognition, 27(3), 160-172, (2014

DOI: 10.1002/jmr.2345

6.    Baud, M., Leiser, T., Petrucci, V., Gunaratnam, M.,

Neidle, S., Meyer-Almes, F-J., & Fuchter, M. J. 

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors. 

Beilstein Journal of Organic Chemistry, 9, 81-88, (2013)

DOI: 10.3762/bjoc.9.11

Meyners 2014 (2).png
Beilstein 2013.png

5.    Baud, M., Leiser, T., Haus, P., Samlal, S., Wong, A. C.,

Wood, R. J., Fuchter, M. J. 

Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets.

Journal of Medicinal Chemistry, 55(4), 1731-1750, (2012)

DOI: 10.1021/jm2016182

defining the mechnaism.gif

4.    Baud, M., Haus, P., Leiser, T., Meyer-Almes, F-J., &

Fuchter, M. J.

Highly ligand efficient and selective N-2-(thioethyl)picolinamide histone deacetylase inhibitors inspired by the natural product psammaplin A. 

ChemMedChem, 8(1), 149-156, (2012)

DOI: 10.1002/cmdc.201200450

ChemMedChem 2012 (1).jpg
ChemMedChem 2012 (2).jpg

3.    Baud, M., Leiser, T., Meyer-Almes, F-J., & Fuchter, M. J. 

New synthetic strategies towards psammaplin A, access

to natural product analogues for biological evaluation.

Organic & Biomolecular Chemistry, 9(3), 659-662, (2011)

DOI: 10.1039/C0OB00824A

new synthetic strategies.gif

2.    Borcard, F., Baud, M., Bello, C., Dal Bello, G., Grossi, F.,

Pronzato, P., ... Vogel, P.  

Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity. 

Bioorganic & Medicinal Chemistry Letters, 20(17), 5353-5356, (2010)

DOI: 10.1016/j.bmcl.2009.09.019


1.    Chauvin, A-S., Comby, S., Baud, M., De Piano, C., Duhot,

C., & Bünzli, J-C. G. 

Luminescent lanthanide helicates self-assembled from ditopic ligands bearing phosphonic acid or phosphoester units. 

Inorganic Chemistry, 48(22), 10687-10696, (2009)

DOI: 10.1021/ic901424w

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