Publications

20. Troup, R. I., Fallan, C., Baud, M. G. J.

Current strategies for the design of PROTAC linkers: a critical

review.

Exploration of Targeted Anti-tumor Therapy, 1, 273-312, (2020).

DOI: 10.37349/etat.2020.00018

19. Chasov, V., Mirgayazova, R., Zmievskaya, E., Khadiullina, R.,

Valiullina, A., Stephenson Clarke, J., Rizvanov, A., Baud, M.,

Bulatov, E.

Key Players in the Mutant p53 Team: Small Molecules, Gene

Editing, Immunotherapy

Frontiers in Oncology, 10, 1460, (2020).

DOI: 10.3389/fonc.2020.01460

18. Baud, M. G. J., Bauer, M. R., Verduci, L., Dingler, F. A., Patel,

K. J., Horil Roy, D., ... Fersht, A. R.

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.

European Journal of Medicinal Chemistry, 152, 101-114, (2018).

DOI: 10.1016/j.ejmech.2018.04.035

17. Runcie, A. C., Zengerle, M., Chan, K-H., Testa, A., van

Beurden, L., Baud, M. G. J., ... Ciulli, A.

Optimization of a “bump-and-hole” approach to allele-selective

BET bromodomain inhibition.

Chemical Science, (2018).

DOI: 10.1039/C7SC02536J

16. Khan, R., Marsh, G., Felix, R., Kemmitt, P. D., Baud, M. G. J.,

Ciulli, A., & Spencer, J.

Gram scale laboratory synthesis of TC AC 28, a high affinity BET bromodomain ligand.

ACS Omega, 2(8), 4328-4332, (2017).

DOI: 10.1021/acsomega.7b00780

15. Weston, C. E., Krämer, A., Colin, F., Yildiz, Ö., Baud, M. G. J.,

Meyer-Almes, F-J., & Fuchter, M. J.

Toward photopharmacological antimicrobial chemotherapy using photoswitchable amidohydrolase inhibitors.

ACS Infectious Diseases, 3(2), 152-161, (2017).

DOI: 10.1021/acsinfecdis.6b00148

14. Bauer, M. R., Jones, R. N., Baud, M., Wilcken, R., Boeckler, F.

M., Fersht, A. R., ... Spencer, J.

Harnessing fluorine–sulfur contacts and multipolar interactions for the design of p53 mutant Y220C rescue drugs.

ACS Chemical Biology, 11(8), 2265-2274, (2016).

DOI: 10.1021/acschembio.6b00315

13. Baud, M., Lin-Shiao, E., Zengerle, M., Tallant, C., & Ciulli, A.

New synthetic routes to triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective bromo and extra-terminal (bet) bromodomain inhibition.

Journal of Medicinal Chemistry, 59(4), 1492-1500, (2016).

DOI: 10.1021/acs.jmedchem.5b01135

12. Richardson, R. D., Baud, M., Weston, C. E., Rzepa, H. S.,

Kuimova, M. K., & Fuchter, M. J.

Dual wavelength asymmetric photochemical synthesis with circularly polarized light.

Chemical Science, 6(7), 3853-3862, (2015).

DOI: 10.1039/C4SC03897E

Eur J Med chem 2018 graphical abstract.j

11. Joerger, A. C., Bauer, M. R., Wilcken, R., Baud, M., Harbrecht,

H., Exner, T. E., ... Fersht, A. R.

Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53.

Structure, 23(12), 2246-2255, (2015).

DOI: 10.1016/j.str.2015.10.016

10. Baud, M. G. J., Lin-Shiao, E., Cardote, T., Tallant, C.,

Pschibul, A., Chan, K-H., ... Ciulli, A.

A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes.

Science, 346(6209), 638-641, (2014).

DOI: 10.1126/science.1249830

9. Meyners, C., Baud, M., Fuchter, M. J., & Meyer-Almes, F-J.

Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors.

Analytical Biochemistry, 460, 39-46, (2014).

DOI: 10.1016/j.ab.2014.05.014

Science 2014 paper graphical abstract (3

Science 2014 paper graphical abstract (2

Science 2014 paper graphical abstract (1

8. Dias, D. M., Van Molle, I., Baud, M., Galdeano, C.,

Geraldes, C. F. G. C., & Ciulli, A. Letter.

Is NMR fragment screening fine-tuned to assess druggability of protein–protein interactions?

ACS Medicinal Chemistry Letters, 5(1), 23-28, (2014).

DOI: 10.1021/ml400296c

7. Meyners, C., Baud, M., Fuchter, M. J., & Meyer-Almes, F-J.

Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes.

Journal of Molecular Recognition, 27(3), 160-172, (2014).

DOI: 10.1002/jmr.2345

6. Baud, M., Leiser, T., Petrucci, V., Gunaratnam, M.,

Neidle, S., Meyer-Almes, F-J., & Fuchter, M. J.

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors.

Beilstein Journal of Organic Chemistry, 9, 81-88, (2013).

DOI: 10.3762/bjoc.9.11

5. Baud, M., Leiser, T., Haus, P., Samlal, S., Wong, A. C.,

Wood, R. J., Fuchter, M. J.

Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets.

Journal of Medicinal Chemistry, 55(4), 1731-1750, (2012).

DOI: 10.1021/jm2016182

4. Baud, M., Haus, P., Leiser, T., Meyer-Almes, F-J., &

Fuchter, M. J.

Highly ligand efficient and selective N-2-(thioethyl)picolinamide histone deacetylase inhibitors inspired by the natural product psammaplin A.

ChemMedChem, 8(1), 149-156, (2012).

DOI: 10.1002/cmdc.201200450

3. Baud, M., Leiser, T., Meyer-Almes, F-J., & Fuchter, M. J.

New synthetic strategies towards psammaplin A, access

to natural product analogues for biological evaluation.

Organic & Biomolecular Chemistry, 9(3), 659-662, (2011).

DOI: 10.1039/C0OB00824A

2. Borcard, F., Baud, M., Bello, C., Dal Bello, G., Grossi, F.,

Pronzato, P., ... Vogel, P.

Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity.

Bioorganic & Medicinal Chemistry Letters, 20(17), 5353-5356, (2010).

DOI: 10.1016/j.bmcl.2009.09.019

1. Chauvin, A-S., Comby, S., Baud, M., De Piano, C., Duhot,

C., & Bünzli, J-C. G.

Luminescent lanthanide helicates self-assembled from ditopic ligands bearing phosphonic acid or phosphoester units.

Inorganic Chemistry, 48(22), 10687-10696, (2009).

DOI: 10.1021/ic901424w